Jeremy W Tomlinson Selected Research

Androgens

1/2021	11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.
1/2021	The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies.
1/2019	A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics.
1/2017	Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.
1/2017	AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome.
8/2015	5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes.
3/2014	Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione.
12/2013	Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.
1/2013	Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.
9/2009	Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.

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Jeremy W Tomlinson Research Topics

Disease

30	Insulin Resistance 01/2023 - 06/2004
26	Obesity 01/2024 - 11/2002
19	Non-alcoholic Fatty Liver Disease 01/2024 - 07/2009
12	Weight Loss (Weight Reduction) 02/2024 - 06/2004
12	Type 2 Diabetes Mellitus (MODY) 12/2023 - 12/2005
10	Cushing Syndrome 04/2017 - 01/2002
9	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2018 - 10/2004
8	Inflammation (Inflammations) 01/2023 - 01/2010
8	Abdominal Obesity 07/2012 - 04/2002
7	Fibrosis (Cirrhosis) 01/2023 - 02/2015
7	Overweight 02/2022 - 07/2009
6	Adrenal Insufficiency (Adrenal Gland Hypofunction) 11/2023 - 01/2006
6	Hypertension (High Blood Pressure) 01/2023 - 06/2003
6	Hepatocellular Carcinoma (Hepatoma) 09/2022 - 05/2014
5	Body Weight (Weight, Body) 01/2024 - 07/2012
5	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2017 - 08/2003
4	Fatty Liver 01/2023 - 12/2013
4	Pseudotumor Cerebri (Idiopathic Intracranial Hypertension) 01/2021 - 12/2010
4	Cortisone reductase deficiency 10/2008 - 08/2003
3	Liver Diseases (Liver Disease) 11/2023 - 02/2015
3	Osteoporosis 01/2023 - 10/2004
3	Neoplasms (Cancer) 01/2022 - 01/2013
3	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 04/2021 - 01/2017
3	Alcoholic Fatty Liver 02/2016 - 11/2013
3	Metabolic Diseases (Metabolic Disease) 01/2016 - 10/2014
3	Glucose Intolerance 06/2014 - 10/2008
3	Muscular Diseases (Myopathy) 06/2014 - 01/2002
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2024 - 11/2015
2	Addison Disease (Addison's Disease) 08/2023 - 01/2020
2	Hyperplasia 04/2017 - 02/2007
2	Diabetes Mellitus 10/2014 - 09/2007
2	Hyperinsulinism (Hyperinsulinemia) 06/2014 - 06/2008
2	Atherosclerosis 09/2010 - 12/2007
2	Pituitary ACTH Hypersecretion 06/2010 - 01/2002
1	Chronic Disease (Chronic Diseases) 09/2023
1	Dizziness (Lightheadedness) 01/2023
1	Fatigue 01/2023
1	Hypoxia (Hypoxemia) 06/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Hypertriglyceridemia 01/2022
1	Prostatic Diseases 01/2021
1	Sarcopenia 01/2021

Drug/Important Bio-Agent (IBA)

36	GlucocorticoidsIBA 11/2023 - 01/2002
22	Hydrocortisone (Cortisol)FDA LinkGeneric 11/2023 - 01/2002
17	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 09/2007
17	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 12/2010 - 01/2002
14	LipidsIBA 06/2022 - 12/2007
13	AndrogensIBA 01/2021 - 08/2003
11	Insulin (Novolin)FDA Link 02/2022 - 11/2007
11	EnzymesIBA 01/2020 - 01/2002
8	SteroidsIBA 01/2024 - 10/2008
8	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 10/2004
7	Biomarkers (Surrogate Marker)IBA 01/2024 - 10/2008
7	Triglycerides (Triacylglycerol)IBA 02/2022 - 07/2012
7	Cortisone FDA Link 01/2012 - 01/2002
6	Adrenocorticotropic Hormone (ACTH)FDA Link 11/2023 - 01/2002
5	Hormones (Hormone)IBA 11/2023 - 06/2010
4	MineralocorticoidsIBA 08/2023 - 10/2014
4	IsotopesIBA 06/2022 - 01/2019
4	galactose-6-phosphate dehydrogenaseIBA 10/2008 - 08/2003
3	FatsIBA 08/2023 - 05/2014
3	Fatty Acids (Saturated Fatty Acids)IBA 06/2022 - 02/2016
3	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2021 - 01/2002
3	Glucagon-Like Peptide 1 (GLP 1)IBA 02/2016 - 11/2013
3	Liraglutide FDA Link 02/2016 - 11/2013
3	Insulin-Like Growth Factor I (IGF-1)IBA 07/2015 - 05/2003
2	CreatinineIBA 12/2023 - 06/2003
2	Proteins (Proteins, Gene)FDA Link 11/2023 - 12/2013
2	RNA (Ribonucleic Acid)IBA 01/2023 - 01/2021
2	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2023 - 06/2020
2	Testosterone (Sustanon)FDA Link 01/2021 - 01/2019
2	2- (1- (5- (cyclohexylcarbamoyl)- 6- propylsulfanylpyridin- 2- yl)- 3- piperidyl)acetic acidIBA 01/2021 - 01/2020
2	Androstenedione (4 Androstene 3,17 dione)IBA 01/2019 - 03/2014
2	Glycerol (Glycerine)FDA LinkGeneric 01/2019 - 06/2008
2	FructoseIBA 01/2016 - 05/2014
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2011 - 01/2002
1	C-PeptideIBA 12/2023
1	Blood Proteins (Serum Proteins)IBA 11/2023
1	ProteomeIBA 11/2023
1	Dipeptidyl-Peptidase IV InhibitorsIBA 01/2023
1	AdipokinesIBA 01/2023
1	ElectrolytesIBA 01/2023
1	IronIBA 01/2023
1	Protons (Proton)IBA 01/2023
1	Vitamin E FDA LinkGeneric 10/2022
1	obeticholic acidIBA 10/2022
1	LigandsIBA 10/2022
1	Pioglitazone (Actos)FDA Link 10/2022
1	Bile Acids and Salts (Bile Acids)IBA 09/2022
1	HDL CholesterolIBA 02/2022
1	Sex Hormone-Binding GlobulinIBA 02/2022
1	Metformin (Glucophage)FDA LinkGeneric 02/2022
1	Immunoglobulin G (IgG)IBA 01/2021
1	LeptinIBA 01/2021

Therapy/Procedure

12	Therapeutics 11/2023 - 01/2013
5	Bariatric Surgery 02/2024 - 01/2021
3	Caloric Restriction 01/2024 - 06/2004
3	Liver Transplantation 06/2020 - 06/2015
2	Drug Therapy (Chemotherapy) 06/2022 - 02/2022
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 12/2023